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Synthetic color for example chocolate color agents decrease rat body weight, serum cholesterol and HDL cholesterol and increase liver enzyme [8,9] Food colorants (amaranth, erythrosine and tartrazine) had a toxic potential to human lymphocytes in vitro and seems that they bind directly to DNA [10]

The lower ( FBXW7 , CSNK1A1 , and METTL14 ) or upper ( PLGRKT ) quartile expression from human patients was directly compared to the opposite quartile