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This lactate clock regulates homeostasis and, in glioblastoma and colorectal cancer, promotes anti-inflammatory cytokines, including interleukin (IL)-10 and IL-6, and tumor progression 42,43,44

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The activity of enzymes involved in its synthesis and degradation, such as choline kinase and phospholipases, is subject to various cellular signals, including nutrient availability and hormonal regulation

The formulation strategy must be tailored to the physicochemical characteristics of the target moleculeits charge, size, hydrophobicity, and structural sensitivity

TP53 loss results in downregulation of mitochondrial respiration and oxidative metabolism, which contribute to the Warburg effect in tumor cells, thus linking to tumor progression (166)