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PTZ is a GABA-A receptor antagonist, it suppresses the function of inhibitory synapses leading to increased neuronal activity (Shimada and Yamagata, 2018)

Lancet (1971) 298(7720):374

After the initial insult resulting in AKI, inflammation within the kidneys is the common denominator that propagates and sustains phases of renal injury [30], ultimately leading to scarring (fibrosis) and permanent loss of function