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doi: 10.1016/j.cell.2012.03.042, 9

No, metformin should generally be continued whilst B12 deficiency is investigated and treated, as it plays an important role in diabetes management

SF (1.25 or 2.5 M treated for 48 h) upregulated Nrf2 expression and facilitated Nrf2 nuclear translocation by reducing DNA methylation of the Nrf2 promoter in a cellular AD model (69)