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By contrast, tight junction barrier loss can be reversed by targeted interventions

Archives of General Psychiatry , 2004;61:866-876

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Those in the methotrexate and folic acid group had received a mean (SD) cumulative methotrexate dose of 184 (72) decigrams over 11 (4) years and had a mean (SD) age of 63 (11) years compared to 59 (11) years for patients on other therapies (Table 1)

Neuroendocrine Integration The combination allows investigation of hypothalamic integration of multi-hormonal signals and downstream metabolic coordination