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Intriguingly, human parkin itself showed glutathione-recycling activity in vitro and in cells: For each GSSG dipeptide encountered, parkin regenerated one GSH molecule and was S -glutathionylated by the other (GSSG + P-SH \(\to\) GSH + P- S -SG), including at cysteines 59, 95 and 377

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For instance, the blood-brain barrier (BBB) is more permeable in early development, facilitating the systemic delivery of gene therapy to a wide range of central nervous system cell types and improving the efficiency of brain transduction

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