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The present invention relates in one embodiment to a vaccine composition comprising one or more pharmamers, wherein the one or more pharmamers comprises more than 1 multimerization domain such as more than 2, 3, 4, 5, 6, 7, 8, 9, 10, 1 1 , 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 200, 300, 400, 500, 600, 700, 800, 900, 1 ,000, 2,000, 3,000, 4,000, 5,000, 6,000, 7,000, 8,000, 9,000, or more thani 0,000 multimerization domains

Perhaps future genetic studies on disease progression will identify more genes and pathways identified in mouse models to control fibrotic responses

Conclusion Mechanical ventilation and critical illness are associated with significant alterations in mucus physiology

82373938, 82104275, 82104276 and 82204585), Key Technologies R&D Program of Guangdong Province (2023B1111030004), National Key R&D Program of China (2022YFF1202600)

Mielgo-Ayuso et al