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Bottiglieri, T., Laundy, M., Crellin, R., Toone, B

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Disruption of the gut microbial communities in Crohns patients has been previously reported, however, these disruptions may either exacerbate disease pathologies or be a consequence of the chronic gut inflammation arising from genetic abnormalities that result in dysfunctional immune signalling

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How This Works The intestinal lining is a single layer of epithelial cells sealed together by tight junctions that control the paracellular pathway the space between cells and thereby regulate what passes from the gut lumen into the tissue