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Gene expression of ERCC1 as a novel prognostic marker in advanced bladder cancer patients receiving cisplatin-based chemotherapy

A formal Phase 2 trial was completed in 2009, but over 15 years later, the results have never been published, another major red flag suggesting it failed to prove effective or safe

Nevertheless, since the risk of cardiovascular and renal events will remain even with the use of GLP-1RA, there is a great deal of clinical interest in its combined use with SGLT2i and finerenone (Table 4)

The exposed caspase recruitment domain (CARD) then recruits and activates the initiator caspase-9, which subsequently cleaves the effector caspase-3, triggering apoptosis (66)