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Cardiovasc Res 2006

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Consider the following loop: Mitochondrial dysfunction impairs ATP production and redox regulation This triggers neuroinflammation and epigenetic dysregulation Which in turn amplifies oxidative stress , weakening mitochondrial resilience further Leading to systemic symptoms: seizures, sleep disturbance, GI dysmotility, developmental regression Importantly, this loop is not a death spiralit is a therapeutic entry point

[DOI] [PubMed] [Google Scholar] Fernandez AM, Torres-Aleman I