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In ME/CFS elevated plasma tryptophan levels may enhance the conversion of tryptophan to 5-hydroxytryptophan in the brain, potentially leading to central fatigue, a core symptom of ME/CFS (Castell et al., 2015)

That is a small rodent study, not human evidence

However, clinically available imaging agents are generally limited by their always on characteristics, which can lead to non-specific imaging interference and false-positive results