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This microbial consortium demonstrates substantial -diversity (intra-individual species richness) and functional redundancy, enabling robust ecosystem stability that facilitates immune tolerance, epithelial barrier maintenance, and metabolic homeostasis through mechanisms including short-chain fatty acid (SCFA) biosynthesis (notably butyrate) and essential vitamin production (Liu et al., 2024

Among people who stop taking dopamine agonists, as many as 20% will experience withdrawal symptoms, such as anxiety, panic attacks, irritability, or drug cravings

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doi: 10.1892/0891-6640(2001)015 2.3.co;2

Unconjugated bilirubin (UCB, i.e., indirect bilirubin) is absorbed actively or passively by hepatocytes, mediated by the hepatic organic anion transporting polypeptides 1B1 (OATP1B1), and passes through uridine glucuronosyltransferase family1 memberA1 (UGT1A1) undergoes mono- or bi-glucuronidation (7) to form bilirubin monoglucuronide or bilirubin bi-glucuronide (i.e., direct bilirubin), which is excreted via the bile ducts by the multidrug resistance protein-2 (MRP2)