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Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

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GHK-Cu is found in blood plasma and is an FDA-approved ingredient in topical antiaging cosmetics but it is currently banned as an injectable because of safety concerns, such as the risk of immune reactions caused by impurities

The comparison period started when both intervention and comparator ceased and the interventions applied to each, if any, were otherwise similar

10.1002/adhm.202001689 25 ChenX.KongX.LiuD.GaoP.ZhangY.LiP.et al (2016)