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Curcumin analog ALZ003 can induce ubiquitination degradation of androgen receptor and significantly increase the sensitivity of GBM cells to temozolomide both in vitro and in vivo, and the mechanism may be related to ROS accumulation, lipid peroxidation and inhibition of GPX4, which are major features of ferroptosis

Neurochem Res 37:27062714 Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, Cotman C, Cottrell B, Montine TJ, Thomas RG, Aisen P, Alzheimer's Disease Cooperative S (2012) Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures

265 Iron overload has been found to decrease lipoprotein lipase activity, thus promoting the development of hypertriglyceridemia

For instance, Akkermansia muciniphila alleviates acetaminophen-induced liver injury by increasing SCFAs secretion to mitigate oxidative stress and inflammation (Xia et al., 2022)

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