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Collectively, understanding the MGBA provides a transformative perspective on neurodegenerative disease mechanisms and offers innovative therapeutic avenues that bridge neurology, microbiology, and precision medicine

Excess ROS accumulates through multiple PD-related mechanisms, including mitochondrial complex 1 impairment, spontaneous dopamine oxidation and chronic exposure to neurotoxic environmental agents

Even though the benefit in BRCA2 is well-established, given the wide range of alterations in a multitude of genes involved in homologous recombination repair, uncertainty exists for the sensitivity of specific alterations and sensitivity to PARPi, primarily as many on an individual basis are rare

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7.6.1 Structural scaffolds: macrocycles and polypyridyl complexes The advancement of ID-ADC has progressively concentrated on refining the structural scaffolds employed for payloads