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Farrell, C

Fluorescence-Based Assays : Some fluorescent probes selectively react with thiols to produce detectable fluorescence signals

For example, in a preclinical study, curcumin was found to reduce levels of heat shock protein 27 (HSP27) and P-glycoprotein (P-gp), causing an increase in the sensitivity of colorectal cancer cells to the chemotherapeutic drug 5-fluorouracil (5-FU), which led to enhanced cell death in 5-FU-resistant HCT-8 cancer cells (He et al

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Conclusions Although increasing numbers of studies performed in vitro and using animal models demonstrate a potential role in dietary prevention of PD, the efficacy of nutritional intervention to do so in humans remains controversial