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Xianmin Meng and Zhiqi Song wrote the manuscript

At the molecular level, homeostasis is controlled by a neuro-endocrine-immune system network wherein LTF plays a central role, largely due to its above-mentioned ability to bind ferric ions

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We reviewed and found that acupuncture can improve the symptoms of patients with PSCI by protecting the IEB, remodeling the structure of gut microbiota, inhibiting inflammation, regulating metabolic pathways and regulating the hypothalamic-pituitary-adrenal (HPA) axis (Tables 1, 2)