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If you don't see anything by week 8, the dose is likely too low or the sourcing is suspect

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Direct comparison of differentially expressed genes (DEGs) in our dataset to previously published datasets revealed that genes upregulated in amdh-1 mutants were also highly upregulated in skn-1(lax188) gain-of-function animals and downregulated in worms treated with skn-1 RNAi (fig 1f) (Nhan et al., 2019

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To bridge these gaps, nextgeneration approaches are under investigation: ADSCderived exosomes as cellfree therapeutics