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20 It is worth noting that gene polymorphisms of liver metabolic enzymes, such as UGT , SULT , and CYP2E1 , and some co-existing diseases, such as viral hepatitis, acute and chronic malnutrition, and nonalcoholic fatty liver disease, may increase the susceptibility to APAP-induced liver injury, even at a therapeutic dose

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EpidemiologyGlobal and Local Insights The global prevalence of G6PD deficiency was estimated to be 4.9% (6), amounting to approximately 400 million people affected worldwide, making it the most prevalent human enzyme deficiency

doi:10.1093/chromsci/bmt066 El-Shaheny RN (2014) Evaluation of agomelatine stability under different stress conditions using an HPLC method with fluorescence detection: application to the analysis of tablets and human plasma