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Human data and transgenic mice have identified many involved proteinases in matrix destruction, including MMP-1, MMP-9, MMP-12, and neutrophil elastase

Crewe C, Joffin N, Rutkowski JM, Kim M, Scherer PE

Increase in hypotonic stress-induced endocytic activity in macrophages via ClC-3

This finding suggests that NM-NP-SPX possesses the potential to substantially mitigate the mortality risk associated with inflammation in patients with sepsis (190)