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Recently, we reported that glycine deficiency led to impairment in the glycine conjugation pathway and resulted in a significant decrease in the elimination of endogenous and exogenous metabolites in individuals with severe obesity 11

Vitamin B12 (cobalamin) is an essential water-soluble vitamin that supports: Red blood cell production Nervous system health Energy metabolism DNA synthesis Many people, especially those with plant-based diets, digestive issues, or fatigue, are deficient in B12

564 Likewise, primary astrocytes prepared from ALS post-mortem samples induced necroptosis of neurones in co-culture, 565 and transplantation of diseased astrocytes into the spinal cord triggered motor deficits and promoted motor neurones degeneration

Anim Biosci 37:106576

Although it's not commonly thought of as a detoxifier, omega-3s can support your body in managing symptoms such as fatigue, poor mood and mental health, an inability to sleep, acne-prone or inflamed skin, and inflammation