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Under normoxic conditions, prolyl hydroxylase (PHD)-mediated hydroxylation of HIF-1 promotes VHL-dependent ubiquitin-proteasome degradation (68)

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Vaz FM, Wanders RJ: Carnitine biosynthesis in mammals

Besides, protein undergoes carbonylation, another form of protein oxidative modification in which ROS groups bind to specific amino acids, affecting protein stability and activity (46)

The same results were found in infected rats (Figure 3)