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MitoQ, a mitochondria-penetrating ubiquinone derivative, restores mitochondrial redox balance and significantly alleviates cachexia-induced muscle wasting in C26 tumor-bearing mice without affecting tumor burden

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NRF2 coordinates with several antioxidant pathways in response to oxidative stress (Figure 2)

Thus, genetic deficiencies in TRAF2, TRAF3, or cIAP1/2 result in NIK accumulation and non-canonical NF-B pathway activation [38,39,40,41]