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Acknowledgements This work was supported by grants from the National Institute of Health (NIH R01HL145031 for ZI, NW, RS, LB, MLY, J.PA., OBU and NIH R21GM136002 for MLY and OBU) and National Science Foundation (NSF EEC-1941543 for ZI, EC, MLY, OBU)

With the accumulation of ROS (oxygen free radicals such as superoxide anion radical and hydroxyl radical), the endogenous antioxidant defense system (i.e., superoxide dismutase, catalase, glutathione ascorbate) fails to counteract ROS generation, resulting in an increase in oxidative stress (28, 33)

All details on statistical analyses as well as outlier detection, are given in Supplementary Table 4

(2000) Vegetable and fruit consumption and risks of colon and rectal cancer in a prospective cohort study: The Netherlands Cohort Study on Diet and Cancer