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NLRP3 inflammasome activation triggers Caspase-1-mediated mitochondrial damage, characterized by increased mtROS production, mitochondrial swelling, and fragmentation, while also inhibiting mitophagy and amplifying mitochondrial damage [11]

Overproduction of ROS and low levels or deactivation of antioxidant machinery causes increased oxidative stress in cancer cells

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In models of water deprivation, puerarin promotes AVP release from the hypothalamic supraoptic nucleus and enhances vasopressin receptor responsiveness in collecting duct epithelia

Hypothyroidism contributes to anxiety by disrupting thyroid hormone levels, which are essential for regulating neurotransmitters like serotonin that maintain mood stability