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Under oxidative stress, ROS modifies occludins and claudins and causes the formation of disulfide bonds, impairing their ability in forming tight junctions and weakening the barrier (89)

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Amino Acids 39 , 15631569 (2010)

Heart failure, especially with reduced ejection fraction (HFrEF), is characterized by impaired pump function usually following myocardial injury, accompanied by neurohormonal activation and pathological remodeling (fibrosis, hypertrophy)