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In STZ-induced DN mouse kidney sections, the outer mitochondrial membrane ruptured, mitochondrial crista disappeared, ACSL4 expression was significantly increased, the levels of oxidative products were elevated, and the level of GPX4 was decreased, indicating that ferroptosis was involved in STZ-induced DN [225]

While Kesikburun showed that the injection of PRP into the subacromial space was not efficacious in the treatment of PRCTs, we are not aware of any studies that have specifically analyzed the efficacy of platelet-rich injections for high-grade intrasubstance partial rotator cuff tears by placing the PRP directly into the rotator cuff tendon [8]

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