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An extreme case was the ketone-bearing MF5 which led to no conversion, whereas the acetal-protected version thereof (MF6) led to 56% yield

Beyond their role in general metabolism, emerging evidence suggests that amino acid metabolic reprogramming plays a crucial role in the pathogenesis of IPF

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Due to the frequency of this metabolic disorder, many physicians have created their own step-wise approaches which have been validated by most medical organizations, including the American Society of Nephrology, which encourages this systematic approach (e.g., Boston approach, Copenhagen approach, Stewart Method)

Elmslie JL, Porter RJ, Joyce PR, Hunt PJ, Mann JI