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The methodologic design of the rescue arm favors the sq methotrexate group, in that, on average, approximately 10% of the subjects in this group received a 25% higher dose of methotrexate than did those in the oral group (who could never receive a dose higher than 15 mg as part of the protocol)

doi:10.1159/000116050 Schneider-Helmert D

But upon testing your serum B12 is decidedly normal or even in the midrange but your MCV is elevated suggesting that the average size of your red blood cells is abnormal

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