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224 Additionally, HIF-1 regulates glutamine metabolism, shifting it toward -ketoglutarate (-KG) production, which fuels fatty acid biosynthesis and prevents lipotoxicity

Environmental Science and Pollution Research, 29 (59), 8898989001

Inflammatory biomarkers, such as hs-CRP and interleukins, serve as indicators for assessing disease risk

Multi-targeted combination therapies are essential: Given metabolic plasticity and heterogeneity, successful therapeutic strategies will require simultaneous targeting of multiple metabolic pathways or combining metabolic inhibitors with other treatment modalities