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Aerts, L., Craessaerts, K., De Strooper, B

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Theoretically, phellodendron might also inhibit the metabolism of midazolam

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Despite being pharmacologically inert on their own, these compounds exhibited a significant impact on the activity of the target compound, giving rise to the concept known as the entourage effect. This effect refers to modifying the pharmacological properties of individual molecules through interactions with co-existing metabolites, even if these metabolites lack inherent pharmacological activity [147]