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A higher proportion of patients receiving elafibranor met either endpoint compared with placebo, regardless of baseline ALP levels, and lower baseline ALP levels yielded higher response rates

Cell-binding peptides PepGen P-15 The P-15 peptide is a highly conserved peptide that consists of 15 amino acids identical to the cell-binding region of collagen type I [234]

After binding of the IFN- proinflammatory cytokine to its receptor, the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway is activated and stimulates the transcription of the chemokine ligands CXCL9 and CXCL10 [53]

The mercapturate is generally more water soluble than is the parent compound and is more readily excreted

When testosterone production declines, lean muscle mass is lost and body fat is increased