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Cells were treated with BSO in the presence or absence of the indicated inhibitor for 24 h to assess the modulating effect of the inhibitor on BSO-induced cytotoxicity

In Embodiment 70 of this disclosure are compounds of Formula or any one of Embodiments 1-69, or a pharmaceutically acceptable salt of any of the foregoing, wherein X and Y are C(R 5 )

Ewa, PK, Giulia, N, Florent, D, Damarys, L, Patrick, P, Yi, X, Kopetz, S , Jennifer, D, Lucie, P, Catherine, RM, Philippe, S, Patrick, TC, Shaynoor, D

The tryptophan 5-hydroxylase 1, crucial for the synthesis of serotonin (5-HT), and tyrosine hydroxylase, a rate-limiting enzyme in the production of dopamine, adrenaline, and noradrenaline, are both positively regulated by SCFAs (175, 176)

The remnants of the dose form reactive metabolites (N-acetyl-p-benzoquinone imine