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Ferroptosis predominantly relies on lipid-derived ROS production but does not engage key regulators of other PCD processes, such as caspases, mixed lineage kinase domain-like protein or Gasdermin-D (GSDMD) (5)

56.4, 112.8 or 225.6 mol /kg/day for 14 days) had congruent protective effects against CIR-induced damage and inflammation (110, 111)

Recently, ferroptosis-based therapy has demonstrated encouraging results in combating cancers, but its potential as a senolytic treatment is yet to be explored 18,19,20

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(2010) 93:S21626