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Two studies from two different institutions recently identified a novel iron death signaling pathway independent of GPX4 (Bersuker et al., As an essential intracellular antioxidant, reduced glutathione (-L-glutamyl-L cysteinylglycine, GSH) synthesis requires the cystine/glutamate antiporter system (encoded by SLC7A11 ) to import cystine from the environment and reduce it to cysteine

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Absence of this important residue in both of its DJ-1 domain might be the probable reason for the complete absence of GLY III activity for AtDJ-1c 33