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[3] In these conditions: the rate of pyruvate production via glycolysis exceeds the rate of its oxidation through the citric acid cycle , so that less than 10% of the pyruvate enters the cycle

Humans and rodents possess four PDK isozymes (PDK1-4), with PDK2 and PDK4 (PDK2/4) exhibiting a more generalized tissue distribution and being significantly associated with metabolic disorders compared to PDK1 and PDK3 (135, 136)

doi: 10.3109/10409238.2011.557713

Recently, several studies have showed that promoting the synthesis of very long chain fatty acids or exogenous supplementation of PUFA enhance necroptosis under oxidative stress [110, 111]