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Metabolomic signatures have been identified for several psychiatric disorders, such as MDD 14 , bipolar disorder 15,16 , and schizophrenia 17,18,19

Ferroptosis Ferroptosis typically results from disruptions in iron metabolism, lipid peroxidation and decreased glutathione (GSH) levels or inactivation of GSH peroxidase 4 (GPX4) (14)

DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request

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10.1016/j.yexcr.2017.10.034 269 WuF.YeH.LinJ.XuY.ZhangZ.XiongH.et al (2018a)