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Furthermore, epigenetic mechanismsincluding DNA methylation, histone acetylation, histone protein variants, and siRNAexert dual regulatory effects: (1) indirectly influencing flavonoid synthesis by altering the expression of pathway-related genes through the MBW complex, and (2) directly regulating structural genes (e.g., CHS, FLS) that encode rate-limiting enzymes in the flavonoid biosynthetic pathway

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The Five Epigenetic Biotypes of Undermethylation were developed within the Second Opinion Physician and WalshDoc framework to organize these broader impediments without replacing Dr

Gao SS, Li DY, Huo ZK, Zhang YL, Cao YZ, Tan YY, et al