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Eyo et al., 7 receptor activation induces cell death, myelin damage, and white matter injury (Matute et al., 2007

Schaefer EJ, Tint GS, Duell PB, Steiner RD

It increases MMPs (e.g., MMP-2, MMP-9) activity and inhibits TIMPs (e.g., TIMP-1, TIMP-2) expression [149], promoting ECM degradation and reducing its accumulation