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After NLRP3 activation, ASC and pro-caspase-1 assemble the NLRP3 inflammasome, which mediates the self-cleavage of pro-caspase-1 and formation of the active caspase-1 p10/p20 tetramer

H., Yip, W., Chou, P

Nucleodur C18 ISIS column (250 mm length x 2 mm i.d., 2.7 m particle size, Macherey-Nagel, Germany, Dren) was used

doi:10.1016/j.ejphar.2010.04.047 85

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