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Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism

Systemic/non-ophthalmic exclusion criteria General history judged by the investigator to be incompatible with the study (for example, life-threatening patient condition or other condition where post-operative follow-up may be difficult)

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This makes it appealing to both men and women who are sensitive to hormonal fluctuations

In addition, it increases oxidative stress and interferes with integrity of DNA, as well as autophagic and apoptotic pathways (22)