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By the time the supplement moves from the stomach into the small intestine, much of the active glutathione has been dismantled into its precursor amino acids

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The KEAP1-Nrf2 complex breaks down when the cell is exposed to oxidative stress, and the released Nrf2 is then transported into the nucleus and binds to antioxidant response elements [25, 26]

thus, any crucial alteration of protein structure/activity is fundamental to understanding how molecular events translate into clinical phenotypes