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70 Srbova J, Krulisova P, Holubova L, Pereiro I, Bendali A, Hamiot A, Podzemna V, Macak J, Dupuy B, Descroix S, et al

Clinical Trial Dosing Ranges Dose Titration Schedules Clinical trials have employed gradual dose escalation to minimize gastrointestinal side effects [9] : Standard Titration Protocol (Example from ONWARDS 1) Rationale: Gradual titration allows tolerance development to gastrointestinal effects (particularly nausea) while building up to therapeutic doses

Thomsen MS, Kostrikov S, Routhe LG, Johnsen KB, Helgudttir SS, Gudbergsson JM, Andresen TL, Moos T (2025) Remodeling of the brain angioarchitecture in experimental chronic neurodegeneration

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