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Adequate micronutrient supplementations are indicated, in addition to supplemental antioxidants, in conditions of suspected mitochondrial dysfunction and periods of oxidative stress

In addition, TMT exposure can trigger neuroinflammatory responses, characterized by increased levels of pro-inflammatory cytokines such as TNF-, IL-1, and nitric oxide, and increased gene expression of the glial fibrillary acidic protein and activated microglia in the brain

In other cell types, arginine synthesis by citrulline is very low but dramatically increases when inducible nitric oxide synthase (NOS) increases (Fig

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The authors further demonstrated the role of TLR-4 in mediating brain injury by generating mice lacking TLR-4 in microglia