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First, the crosstalk network between distinct ferroptosis-regulating pathways (System Xc GSHGPX4 axis, lipid peroxidation, iron metabolism, and epigenetic regulation) remains poorly definedwhether these pathways act in a hierarchical, synergistic, or compensatory manner in different phases of I/R injury (ischemia vs

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This intriguing hypothesis awaits formal validation and is not fully corroborated by epidemiological evidence [35]

Deeply elucidating these immune mechanisms is essential for developing novel prevention and treatment strategies

238 studied genes related to glutaminolysis in order to determine the sensitivity of glutamine metabolism to xCT-targeted therapy in head and neck squamous cell carcinoma