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155 The approval was based on findings from two phase III, randomized, controlled trials with a combined total of 960 participants with fibromyalgia

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Phase 2 trials demonstrated 10.6% mean body weight reduction at 24 weeks on 0.5mg daily tesofensine versus 2% placebo, with most effect attributed to reduced caloric intake rather than increased thermogenesis

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Vitamin D may influence glucose metabolism through multiple biological mechanisms, including insulin secretion and insulin sensitivity