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Huanglian-Houpo extract attenuates DSS-induced UC mice by protecting intestinal mucosal barrier and regulating macrophage polarization

In animal studies, it has been shown to decrease body fat and increase lean muscle mass

Mihm et al, 1999), is involved in the oxidant stress-mediated regulation of numerous gene expression, particularly at the transcriptional level

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While it was shown to slow cancer cell proliferation in vitro and in xenografts [38] , its moderate potency (IC 50 = 3.3 mol/L), poor metabolic stability and low solubility, limit its potential use in the clinical setting [39]