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10.1073/pnas.0711067105 Proc

Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4 + T cell metabolic rewiring

In addition to the leak and pore pathways, there is also the unrestricted (or apoptotic) pathway, where severe damage to the gut mucosa results in death of epithelial cells and permits unrestricted paracellular transport of large molecules and bacteria