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That activity is also what makes them reactive

Fine line reduction (weeks 6 to 12): shallow dynamic lines around the eyes and mouth soften as the surrounding matrix becomes better hydrated and structurally supported

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This leads to an increase in the activity of the glutathione-dependent enzymes, glutathione reductase and glutamate-cysteine ligase, and the glutamate/cystine antiporter, which are critical in the production of reduced glutathione, which plays a vital role in neutralizing ROS (Lee et al., 2003

doi: 10.1038/s41746-024-01043-6