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Cisplatin is an antitumor drug, and its uptake is mediated by copper transporter CTR1 inside the cell (178)

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[374], who also observed that chlorogenic acid suppressed the activation of pro-inflammatory and apoptotic signaling pathways in these animals

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Additionally, the activation of GPR18 may further amplify these effects through increased nNOS activity and reduced oxidative stress

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Liver and Brain Dysfunction When oxygen levels drop below 2%, the liver reduces hemoglobin production, leading to hypoxia, impaired energy production, and increased red blood cell (RBC) destruction.76 Chronic liver damage is linked to processing RBC byproducts like hemoglobin, iron, and cholesterol, which accumulate in organs like the liver, pancreas, and bone marrow, disrupting metabolism

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10.1080/26895293.2020.1771434 Summary Keywords Stevia rebaudiana Bertoni, ethnobotany, traditional medicine applications, bioactivity, health promotion Citation Wang L, Chang T, Zhu T, Hu W, Wang X, Dong C, Sun Y, Zhang T, Jiang Y, Zhao C, Cui Y, Guo J and Liao X (2025) Stevia rebaudiana Bertoni as a sweet herbal medicine: traditional uses, potential applications, and future development

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